V5
王蕊 声望 48
医学
A review of the biomaterials technologies for infection-resistant surfaces
作者:Davide Campoccia a,**, Lucio Montanaro a,b , Carla Renata Arciola a,b,*
摘要:Anti-infective biomaterials need to be tailored according to the specific clinical application. All their properties have to be tuned to achieve the best anti-infective performance together with safe biocom- patibility and appropriate tissue interactions. Innovative technologies are developing new biomaterials and surfaces endowed with anti-infective properties, relying either on antifouling, or bactericidal, or antibiofilm activities. This review aims at thoroughly surveying the numerous classes of antibacterial biomaterials and the underlying strategies behind them. Bacteria repelling and antiadhesive surfaces, materials with intrinsic antibacterial properties, antibacterial coatings, nanostructured materials, and molecules interfering with bacterial biofilm are considered. Among the new strategies, the use of phages or of antisense peptide nucleic acids are discussed, as well as the possibility to modulate the local im- mune response by active cytokines. Overall, there is a wealth of technical solutions to contrast the establishment of an implant infection. Many of them exhibit a great potential in preclinical models. The lack of well-structured prospective multicenter clinical trials hinders the achievement of conclusive data on the efficacy and comparative performance of anti-infective biomaterials.
关键词:Implant infections Anti-infective biomaterials Antiadhesive surfaces Nanostructured materials Antibiofilm molecules Antisense peptide nucleic acids (PNAs)
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发表期刊:
数字识别码:10.1016/j.biomaterials.2013.07.089
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