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雪舞梅香 声望 4
生物科学与技术系
MiR-204, down-regulated in retinoblastoma, regulates proliferation and invasion of human retinoblastoma cells by targeting CyclinD2 and MMP-9
作者:, JunFa Xu
摘要:Abstract Aberrant expression of miR-204 had been frequently reported in cancer studies; however, the mechanism of its function in retinoblastoma remained unknown. Here, we reported that miR-204 was frequently downregulated in retinoblastoma tissues and cell lines. Enforced expression of miR-204 inhibited retinoblastoma cells’ proliferation and invasion. In vivo study indicated that restoration of miR-204 inhibited tumor growth. CyclinD2 and MMP-9 were identified as potential targets of miR-204. In addition, a reverse correlation between miR-204 and CyclinD2 or MMP-9 expression was noted in retinoblastoma tissues. Taken together, our results identified a crucial tumor suppressive role of miR-204 in the progression of retinoblastoma.
关键词:miR-204; CyclinD2; MMP-9; Retinoblastoma
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发表期刊:FEBS Letters Volume 589, Issue 5
发表时间:Fri Feb 27 00:00:00 CST 2015
数字识别码:10.1016/j.febslet.2015.01.030
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