V1
Blaine 声望 1
生物信息学
Huaier suppresses proliferation and induces apoptosis in human pulmonary cancer cells via upregulation of miR-26b-5p
作者:, Zhongxin Lu
摘要:Abstract Various studies have reported that Huaier possesses anti-tumor effects. However, the mechanisms are not completely elucidated. Here, we found 66 differentially expressed miRNAs in Huaier-treated pulmonary adenocarcinoma A549 cells, with upregulation of miR-26b-5p. Transfection of A549 cells with miR-26b-5p mimic inhibited proliferation and induced apoptosis, while transfection of Huaier-treated A549 cells with a miR-26b-5p inhibitor reversed the effects of Huaier. EZH2 was verified as the target of miR-26b-5p. Thus, our findings indicate that Huaier might suppress proliferation and induce apoptosis in lung cancer cells via a miR-26b-5p-EZH2-mediated approach, which provides a new perspective for understanding the anti-tumor effects of Huaier.
关键词:miR-26b-5p; Huaier; Lung cancer; EZH2; Proliferation; Apoptosis
论文方向:
发表期刊:FEBS Letters Volume 588, Issue 12
发表时间:Thu Jun 05 00:00:00 CST 2014
数字识别码:10.1016/j.febslet.2014.04.044
是否作者本人:

版权及免责声明:

本网站所有论文文件均系用户自行上传或提供,本网站对其内容准确性及合法性概不负责,亦不承担任何法律责任。论文版权归原作者及原出处所有。

如您发现网站其他用户上传的论文有侵犯您的姓名权、隐私权、著作权或其他合法权益现象的,请及时与本网站联系并附加相关权利证明文件,以便本网站及时作出处理,维护您的合法权益。

本网站拥有对此声明的最终解释权。

全部评论 ( 0 )

发评论
5.0/10分

0人评分