V2
寻麦 声望 18
生物科学与生物技术
Inhibitory role of polyunsaturated fatty acids on lysophosphatidic acid-induced cancer cell migration and adhesion
作者:, Sun Sik Bae
摘要:Abstract Polyunsaturated fatty acids (PUFAs) have important pharmacological effects on mammalian cells. Here, we show that carboxyl group-containing PUFAs inhibit lysophosphatidic acid (LPA)-induced focal adhesion formation, thereby inhibiting migration and adhesion. Carboxyl group-containing PUFAs inhibit LPA-induced calcium mobilization, whereas ethyl ester-group containing PUFAs have no effect. In addition, carboxyl group-containing PUFAs functionally inhibit LPA-dependent RhoA activation. Given these results, we suggest that PUFAs may inhibit LPA-induced calcium/RhoA signaling pathways leading to focal adhesion formation. Carboxyl group-containing PUFAs may have a functional role in this regulatory mechanism.
关键词:AA arachidonic acid; arachidonic acid; CaM calmodulin; calmodulin; CaMKII CaM-dependent kinase II; CaM-dependent kinase II; DHA docosahexaenoic acid; docosahexaenoic acid; ECM extracellular matrix; extracellular matrix; ELA ethyl linoleate; ethyl linoleate; ELN ethyl linolenate; ethyl linolenate; EPA eicosapentaenoic acid; eicosapentaenoic acid; FAs focal adhesions; focal adhesions; LA linoleic acid; linoleic acid; LNA α-linolenic acid; α-linolenic acid; LPA lysophosphatidic acid; lysophosphatidic acid; PUFAs polyunsaturated fatty acids; polyunsaturated fatty acids; α-Linolenic acid; Lysophosphatidic acid; Migration; Adhesion; Vinculin; Calcium mobilization
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发表期刊:FEBS Letters Volume 588, Issue 17
发表时间:Mon Aug 25 00:00:00 CST 2014
数字识别码:10.1016/j.febslet.2014.05.052
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