V2
孔济夫 声望 6
生物科学
MicroRNA profiling during rat ventricular maturation: A role for miR-29a in regulating cardiomyocyte cell cycle re-entry
作者:, Zhe Zheng
摘要:Abstract Recent studies demonstrated that the mammalian heart possesses some capacity to proliferate. We observed cardiomyocyte proliferation within 4 weeks of age (P4W) in rats. We found 95 microRNAs that are differentially expressed in P4W cardiomyocytes. MicroRNA-29a was among the most highly up-regulated microRNAs in P4W cardiomyocytes. Overexpression of microRNA-29a suppressed the proliferation of H9c2 cell line. MicroRNA-29a inhibition induced cardiomyocytes to proliferate, accelerated the G1/S and G2/M transition, and up-regulated the cell cycle gene expression. Cyclin D2 (CCND2) was identified as a direct target of microRNA-29a. These findings indicate that microRNA-29a is involved in cardiomyocyte proliferation during postnatal development.
关键词:miRNA microRNAs; microRNAs; CCND2 cyclin D2; cyclin D2; CDK2 cyclin-dependent kinase 2; cyclin-dependent kinase 2; P2 postnatal day 2; postnatal day 2; P4W 4 weeks of age; 4 weeks of age; GAPDH glyceraldehyde-3 phosphate dehydrogenase; glyceraldehyde-3 phosphate dehydrogenase; UTR untranslated regions; untranslated regions; MicroRNA; Cardiomyocyte; Proliferation; Microarray; MicroRNA-29a
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发表期刊:FEBS Letters Volume 587, Issue 10
发表时间:Tue May 21 00:00:00 CST 2013
数字识别码:10.1016/j.febslet.2013.01.075
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