Increase of c-jun mRNA upon hypo-osmotic cell swelling of rat hepatoma cells
作者:, Dieter Häussinger
摘要:Abstract c-jun mRNA levels were increased in rat hepatoma cells (H4-II-E-C3) when exposed to hypotonie medium (205 mosmoll) with a maximal induction observed after 1 h of hypotonie exposure. At this time point an approximate 5-fold increase in c-jun expression could be detected in relation to nonnotonic control incubations (305 mosmoll). Hypertonic exposure (405 mosmol/1) had only a slight effect on c-jun expression. In contrast to the increased c-jun mRNA levels under hypotonic conditions, expression of the c-fos proto-oncogene was unaffected by changes in the osmolarity. The hypotonicity-induced increase in c-jun expression was also detectable in the presence of a protein kinase C (PKC) inhibitor. This indicates that PKC is not involved in the signal transduction pathway leading to c-jun expression upon hypotonic cell swelling in these cells.
关键词:c-jun; c-fos; Proto-oncogene; Cell swelling; Hypotonic; Hypertonic; Protein kinase C; Hepatoma cell; PKC, protein kinase C; PMA, phorbol 12-myristate 13-acetate.
论文方向:
发表期刊:FEBS Letters Volume 340, Issue 3
发表时间:Mon Mar 07 00:00:00 CST 1994
数字识别码:10.1016/0014-5793(94)80129-0
是否作者本人:

版权及免责声明:

本网站所有论文文件均系用户自行上传或提供,本网站对其内容准确性及合法性概不负责,亦不承担任何法律责任。论文版权归原作者及原出处所有。

如您发现网站其他用户上传的论文有侵犯您的姓名权、隐私权、著作权或其他合法权益现象的,请及时与本网站联系并附加相关权利证明文件,以便本网站及时作出处理,维护您的合法权益。

本网站拥有对此声明的最终解释权。

全部评论 ( 0 )

发评论
5.0/10分

0人评分