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晨露不怕晚 声望 32
生物化学与分子生物学
Saturated fatty acid-induced miR-195 impairs insulin signaling and glycogen metabolism in HepG2 cells
作者:, Wan Lee
摘要:Abstract MicroRNAs (miRNAs) play an important role in insulin signaling and insulin secretion, but the role of miRNAs in the association between obesity and hepatic insulin resistance is largely unknown. This study reports that saturated fatty acid (SFA) and high fat diet (HFD) significantly induce miR-195 expression in hepatocytes, and that the insulin receptor (INSR), not insulin receptor substrate-1 (IRS-1), is a direct target of miR-195. Furthermore, the ectopic expression of miR-195 suppresses the expression of INSR, thereby impairing the insulin signaling cascade and glycogen synthesis in HepG2 cells. These findings suggest that the dysregulation of miR-195 by SFA is a detrimental factor for hepatic insulin sensitivity.
关键词:MicroRNA; MiR-195; Saturated fatty acid; Palmitate; Insulin resistance; Insulin receptor; Insulin receptor substrate-1
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发表期刊:FEBS Letters Volume 588, Issue 21
发表时间:Mon Nov 03 00:00:00 CST 2014
数字识别码:10.1016/j.febslet.2014.09.006
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