V2
本木布 声望 6
生物信息技术
Ceramide-1-phosphate: a novel regulator of cell activation
作者:Antonio Gómez-Muñoz
摘要:Abstract Ceramide-1-phosphate (Cer-1-P) is emerging as a novel bioactive sphingolipid. It is formed by phosphorylation of ceramide catalyzed by ceramide kinase, and has been implicated in different cellular processes. Cer-1-P is mitogenic for fibroblasts, blocks apoptosis in macrophages, controls phagocytosis in neutrophils, and mediates inflammatory responses. Only recently have we started to uncover the signaling pathways that are affected by Cer-1-P. Recent work has demonstrated that cytosolic phospholipase A2 and acid sphingomyelinase are direct intracellular targets of Cer-1-P, and that it may also induce phosphorylation of extracellular signal-regulated kinase-2 and calcium mobilization. These actions of Cer-1-P seem to be cell type-specific.
关键词:Apoptosis; cell proliferation; Ceramide-1-phosphate; Sphingolipid; Sphingosine-1-phosphate; Sphingomyelinase; C2-ceramide, N-acetylsphingosine; C8-ceramide, N-octanoylsphingosine; Cer-1-P, ceramide-1-phosphate; ERK, extracellular signal-regulated kinase; MAPK, mitogen-activated protein kinase; PA, phosphatidate; PKC, protein kinase C; PLA2, phospholipase A2; PLD, phospholipase D; SM, sphingomyelin; Sph-1-P, sphingosine-1-phosphate
论文方向:
发表期刊:FEBS Letters Volume 562, Issues 1–3
发表时间:Fri Mar 26 00:00:00 CST 2004
数字识别码:10.1016/S0014-5793(04)00211-X
是否作者本人:

版权及免责声明:

本网站所有论文文件均系用户自行上传或提供,本网站对其内容准确性及合法性概不负责,亦不承担任何法律责任。论文版权归原作者及原出处所有。

如您发现网站其他用户上传的论文有侵犯您的姓名权、隐私权、著作权或其他合法权益现象的,请及时与本网站联系并附加相关权利证明文件,以便本网站及时作出处理,维护您的合法权益。

本网站拥有对此声明的最终解释权。

全部评论 ( 0 )

发评论
5.0/10分

0人评分