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贾志强 声望 1
生物信息学与生物统计学
Human monocyte-derived dendritic cells are deficient in prostaglandin E2 production
作者:, Martin Thurnher
摘要:Abstract Monocyte-derived dendritic cells (moDCs) are increasingly used in clinical settings to stimulate tumor immunity. Prostaglandin E2 (PGE2), which is a member of the eicosanoid family of oxygenated arachidonic acid derivatives generated through the action of cyclooxygenases (COXs), is frequently used to enhance the tumor necrosis factor-α-induced terminal maturation of moDCs. We show here that one effect of interleukin (IL)-4, which is used together with GM-CSF to generate moDCs, is the suppression of endogenous PGE2 production in moDCs. IL-4 inhibits the cytoplasmic form of phospholipase A2, the enzyme that specifically liberates arachidonic acid from membrane phospholipids. Although moDCs failed to mobilize endogenous arachidonic acid, they converted exogenous arachidonic acid into PGE2 in a COX-1- and COX-2-dependent fashion. IL-4-mediated suppression of PGE2 biosynthesis in human moDCs explains the previously reported maturation-enhancing effect of exogenous PGE2. The general suppression of eicosanoid biosynthesis may, however, limit the immunological efficacy of moDCs generated with IL-4.
关键词:Dendritic cell; Monocyte-derived; Arachidonic acid; Phospholipase A2; Eicosanoid
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发表期刊:FEBS Letters Volume 511, Issues 1–3
发表时间:Wed Jan 30 00:00:00 CST 2002
数字识别码:10.1016/S0014-5793(01)03326-9
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