Tsp66E, the Drosophila KAI1 homologue, and Tsp74F function to regulate ovarian follicle cell and wing development by stabilizing integrin localization
摘要：Abstract The metastasis suppressor KAI1/CD82 has been implicated in various cellular processes; however, its function in development is not fully understood. Here, we generated and characterized mutants of Tsp66E and Tsp74F, which are Drosophila homologues of KAI1/CD82 and Tspan11, respectively. These mutants exhibited egg elongation defects along with disturbed integrin localization and actin polarity. Moreover, the defects were enhanced by mutation of inflated, an αPS2 integrin gene. Mutant ovaries had elevated αPS2 integrin levels and reduced endocytic trafficking. These results suggest that Drosophila KAI1/CD82 affects the polarized localization and the level of integrin, which may contribute to epithelial cell polarity.
关键词：KAI1 kangai1; kangai1; if inflated; inflated; PS position specific; position specific; Tsp tetraspanin; tetraspanin; Integrin; KAI1/CD82; Tsp66E; Tsp74F; Tspan11; Drosophila
论文方向：[{"id":13,"name":"细胞生物学"},{"id":879,"name":"生物化学"}]
发表期刊：FEBS Letters Volume 586, Issue 22
发表时间：Fri Nov 16 00:00:00 CST 2012
数字识别码：10.1016/j.febslet.2012.09.044
是否作者本人： 否
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