V1
程强 声望 1
动物生物技术
Molecular cloning of rat GADD45γ, gene induction and its role during neuronal cell death
作者:, Tsuneaki Sakata
摘要:Abstract To study the molecular mechanism of neuronal cell death, we carried out the screening of genes which were induced during the neuronal cell death of neuronal PC12. We cloned the cDNA of rat GADD45γ, the third member of the GADD45 family. Induction of GADD45γ mRNA was observed in the neuronal cell death caused by depletion of neurotrophic factor and Ca2+ ionophore treatment. Overexpression of GADD45γ in superior cervical ganglion neurons caused cell death. These results suggest that GADD45γ plays an important role in neuronal cell death.
关键词:Restriction landmark cDNA scanning; Microinjection; GADD, growth arrest and DNA damage-induced protein; NGF, nerve growth factor; SCG, superior cervical ganglia
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发表期刊:FEBS Letters Volume 446, Issues 2–3
发表时间:Fri Mar 12 00:00:00 CST 1999
数字识别码:10.1016/S0014-5793(99)00234-3
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