Aberrant expression and function of p53 in T-cells immortalized by HTLV-I Tax1
作者:, Kunitada Shimotohno
摘要:Abstract The expression and function of p53 tumor suppressor protein was investigated in T-cells immortalized by the Tax1 protein of HTLV-I. Conformationally wild-type p53 was expressed at elevated levels in Tax1-immortalized T-cells by post-transcriptional mechanisms when compared with normal T-cells. Luciferase assays with a reporter plasmid containing p53-binding sites revealed an impairment in the transactivating function of p53 in Tax1-immortalized T-cells. Our results suggest an important role for Tax1 in the aberrant expression and function of p53 observed in many HTLV-I transformed cells.
关键词:HTLV-I; Tax1; p53; Transcription; Transactivation
论文方向:[{"id":13,"name":"细胞生物学"},{"id":879,"name":"生物化学"}]
发表期刊:FEBS Letters Volume 406, Issue 3
发表时间:Mon Apr 14 00:00:00 CST 1997
数字识别码:10.1016/S0014-5793(97)00280-9
是否作者本人: 否
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