V2
地道风物 声望 11
生物技术
Preparation and neutralization characteristics of an antibody to the factor inducing differentiation of mouse myeloid leukemic cells
作者:, M. Hozumi
摘要:Abstract Mouse myeloid leukemic M1 cells can be induced to differentiate into macrophages and granulocytes in vitro by a protein inducer (D-factor) in body fluids and conditioned media from various cells and tissues. Antiserum to D-factor was prepared by immunizing a rabbit with D-factor partially purified from conditioned medium of mouse L929 cells. At 1:20 dilution, the antiserum nearly completely suppressed the activities of various D-factor preparations from mice and partially suppressed the activities of preparations from rats and hamsters. It did not cross-react with factors stimulating colony formation of macrophages and granulocytes from normal bone marrow cells.
关键词:Myeloid leukemic cell; Differentiation factor; Antibody; Bone marrow cell; Colony-stimulating factor; D-factor differentiation-stimulating factor; differentiation-stimulating factor; MGI macrophage and granulocyte inducer; macrophage and granulocyte inducer; CSF colony-stimulating factor; colony-stimulating factor; G-CSF granulocyte colony-stimulating factor; granulocyte colony-stimulating factor; CM conditioned medium; conditioned medium
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发表期刊:FEBS Letters Volume 151, Issue 2
发表时间:Mon Jan 24 00:00:00 CST 1983
数字识别码:10.1016/0014-5793(83)80087-8
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