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心海涤尘 声望 12
动植物检疫
Phosphorylation of Serine422 increases the stability and transactivation activities of human Osterix
作者:, Changyan Ma
摘要:Abstract Osterix (Osx) is an essential regulator for osteoblast differentiation and bone formation. Although phosphorylation has been reported to be involved in the regulation of Osx activity, the precise underlying mechanisms remain to be elucidated. Here we identified S422 as a novel phosphorylation site of Osx and demonstrated that GSK-3β interacted and co-localized with Osx. GSK-3β increased the stability and transactivation activity of Osx through phosphorylation of the newly identified site. These findings expanded our understanding of the mechanisms of posttranslational regulation of Osx and the role of GSK-3β in the control of Osx transactivation activity.
关键词:Osterix; Osteoblast differentiation; Phosphorylation modification; Mass spectrometric analysis; Protein stability; Transactivation activity
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发表期刊:FEBS Letters Volume 589, Issue 7
发表时间:Tue Mar 24 00:00:00 CST 2015
数字识别码:10.1016/j.febslet.2015.02.021
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